Synthesis and X-ray crystal structure of the calcium channel antagonist: dimethyl 1,4-dihydro-2,6-dimethyl-4-[4 '-(4H-4-oxo-1-benzopyran-2-yl)phenyl]-3,5-pyridine dicarboxylate

Tuncbilek M., Ozbey S., Kendi E., Yildirim E., Erol K., Ertan R.

FARMACO, vol.54, no.10, pp.660-665, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 10
  • Publication Date: 1999
  • Doi Number: 10.1016/s0014-827x(99)00076-2
  • Journal Name: FARMACO
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.660-665
  • Keywords: flavonyldihydropyridine, calcium antagonistic activity, X-ray structure analysis, CONFORMATION, DERIVATIVES, NIFEDIPINE, RECEPTOR, BINDING
  • Ankara University Affiliated: Yes

Abstract

The synthesis of the title compound via the Hantzsch method from 4'-flavone carboxaldehyde is described, and its molecular structure was determined by X-ray crystallography. The 1,4-dihydropyridine (1,4-DHP) ring adopts a boat conformation. The phenyl ring of the flavone is not exactly perpendicular to the DHP ring. Calcium antagonistic activity of this compound was evaluated in vitro by using BaCl2-stimulated rat ileum. (C) 1999 Elsevier Science S.A. All rights reserved.