Kidney biopsy in AA amyloidosis: impact of histopathology on prognosis

Celebi Z. K., KİREMİTCİ S., Ozturk B., Akturk S., Erdogmus S., Duman N., ...More

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, vol.24, no.3, pp.176-182, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.1080/13506129.2017.1350158
  • Journal Name: AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.176-182
  • Keywords: AA amyloidosis, amyloid deposition pattern, end-stage renal disease, glomerular filtration rate, renal pathology, RENAL AMYLOIDOSIS, SYSTEMIC AMYLOIDOSIS, CLINICAL-FEATURES, SURVIVAL, PROTEIN
  • Ankara University Affiliated: Yes

Abstract

In AA amyloidosis, while kidney biopsy is widely considered for diagnosis by clinicians, there is no evidence that the detailed investigation of renal histopathology can be utilized for the prognosis and clinical outcomes. In this study, we aimed to obtain whether histopathologic findings in kidney biopsy of AA amyloidosis might have prognostic and clinical value. This is a retrospective cohort study that included 38 patients who were diagnosed with AA amyloidosis by kidney biopsy between 2005 and 2013. The kidney biopsy specimens of patients were evaluated and graded for several characteristics of histopathological lesions and their relationship with renal outcomes.