Development of a Diamond Nanoparticles-based Nanosensor for Detection and Determination of Antiviral Drug Favipiravir

Dindar C. K., BOZAL PALABIYIK B., USLU B.

ELECTROANALYSIS, vol.34, no.7, pp.1174-1186, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 7
  • Publication Date: 2022
  • Doi Number: 10.1002/elan.202100571
  • Journal Name: ELECTROANALYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, BIOSIS, Chimica, Communication Abstracts, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.1174-1186
  • Keywords: Favipiravir, diamond nanoparticles, carbon paste electrode, voltammetry, validation, ELECTROCHEMICAL SENSOR, SILVER NANOPARTICLES, SENSITIVE DETERMINATION, ELECTRODE, COVID-19
  • Ankara University Affiliated: Yes

Abstract

This study developed a nanosensor for the detection and determination of favipiravir, a presumed drug that has potential therapeutic efficacy in treating COVID-19 patients, from tablets and serum samples. This nanosensor was obtained by adding the optimum amount of diamond nanoparticles into carbon paste. For the determination of favipiravir adsorptive stripping differential pulse (AdSDPV) and adsorptive stripping square wave voltammetry (AdSSWV) were used. Limit of detection values were found as 4.83 x 10(-9) M and 2.44 x 10' M for bulk and 5.18 x 10(-8) M and 4.38 x 10(-8) M for serum samples using AdSDPV and AdSSWV, respectively. Recovery studies made of the tablet and serum produced satisfactory results.