Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

Creative Commons License

Ma C. S., Wong N., Rao G., Avery D. T., Torpy J., Hambridge T., ...More

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.136, no.4, pp.993-1007, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 136 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1016/j.jaci.2015.05.036
  • Journal Name: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.993-1007
  • Keywords: Follicular helper T cells, humoral immunity, primary immunodeficiencies, cytokine signaling, TRANSCRIPTION FACTOR STAT3, ANTIBODY-RESPONSES, HUMORAL IMMUNITY, IL-21 RECEPTOR, IFN-GAMMA, B-CELLS, DEFICIENCY, PHENOTYPE, AGAMMAGLOBULINEMIA, COMMITMENT
  • Ankara University Affiliated: Yes

Abstract

Background: Follicular helper T (T-FH) cells underpin T cell-dependent humoral immunity and the success of most vaccines. T-FH cells also contribute to human immune disorders, such as autoimmunity, immunodeficiency, and malignancy. Understanding the molecular requirements for the generation and function of T-FH cells will provide strategies for targeting these cells to modulate their behavior in the setting of these immunologic abnormalities.