Electrochemical reduction and oxidation of the antibiotic cefepime at a carbon electrode

Ozkan S. A., Uslu B., Zuman P.

Analytica Chimica Acta, vol.457, no.2, pp.265-274, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 457 Issue: 2
  • Publication Date: 2002
  • Doi Number: 10.1016/s0003-2670(02)00022-3
  • Journal Name: Analytica Chimica Acta
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.265-274
  • Keywords: cefepime, voltammetry, carbon electrode, CEPHALOSPORIN ANTIBIOTICS, VOLTAMMETRY
  • Ankara University Affiliated: Yes

Abstract

The O-methyl oxime grouping in the antibiotic cefepime is reduced in aqueous buffer solution at pH<8 at a carbon electrode. The reduction of the protonated form of the oxime occurs in a single two-electron step. By comparison with anodic wave of 2-aminothiazole it was furthermore shown that the oxidation of cefepime involves the 2-amino group located on the thiazole ring in the side chain on C-7. Both reduction and oxidation peaks can be used for analytical purposes. © 2002 Elsevier Science B.V. All rights reserved.