© 2018 Tasar?m / Design Kayhan Bolelli.Objective: Proper care of contact lens is important for preventing contact lens related infections and for maintaining eye health. Multi-purpose solutions are used for various purposes such as cleaning, rinsing, disinfecting, and storing soft contact lenses. Material and Method: In our work, the activities of four commercially available multi-purpose contact lens care solutions (MPCLCSs) were investigated. For this purpose, six microorganisms, including five strains of bacteria and one of yeast, were used and four Multi-Purpose Solutions including ReNu® MultiPlus, Opti-Free® Express, All In One Light, BiotrueTM were evaluated. S. epidermidis ATCC 35948 (biofilm forming), S. epidermidis ATCC 12228 (non-biofilm forming), Pseudomonas aeruginosa ATCC 9027, Staphylococcus aureus ATCC 25923, S. aureus ATCC 43300 (methicillin resistant) and Candida albicans ATCC 10231 were used as test microorganisms. The quantitative suspension test was performed and results were evaluated in accordance with EN ISO 14729 Stand-alone test primary criteria. According to the mean log reduction values for 6 h contact time, all the MPCLCSs were found effective against test microorganisms. Result and Discussion: There are various types of commercial MPCLCSs available on the market. The antimicrobial efficacies of these products depend on the type and concentrations of the antimicrobial agents present in their content. In this study, all the MPCLCSs were found effective against test microorganisms at manufacturer's recommended contact time.