Electrochemical Investigations and Molecular Docking Analysis to Evaluate the Molnupiravir-Calf Thymus dsDNA Interaction

Kucuk I., ÜNAL M. N., Karayel A., KURBANOĞLU S., USLU B.

Journal of the Electrochemical Society, cilt.171, sa.5, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 171 Sayı: 5
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1149/1945-7111/ad3feb
  • Dergi Adı: Journal of the Electrochemical Society
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Analytical Abstracts, Applied Science & Technology Source, Chemical Abstracts Core, Chimica, Compendex, Computer & Applied Sciences, INSPEC
  • Anahtar Kelimeler: binding constant, deoxyribonucleic acid, electrochemical biosensor, interaction, molecular docking, molnupiravir
  • Ankara Üniversitesi Adresli: Evet

Özet

Highlights This electrochemical study examined Molnupiravir’s (MLP) interaction with calf thymus double-stranded DNA (ct-dsDNA) for the first time. In a solution with both, the biosensor surface investigated the interaction of ct-dsDNA immobilized on the GCE surface and the bare GCE examined the interaction of MLP-ct-dsDNA. Differential pulse voltammetry shows that MLP-dAdo binding mode decreases oxidation signals after incubation with various doses. The binding constant of MLP and ct-dsDNA was calculated using cyclic voltammetry. A molecular docking simulation contributed electrochemical interaction study.