Electroanalytical Investigation and Simultaneous Determination of Etodolac and Thiocolchicoside at a Non-Modified Glassy Carbon Electrode in Anionic Surfactant Media

Selcuk O., Erkmen C., BOZAL PALABIYIK B., USLU B.

ELECTROANALYSIS, vol.33, no.5, pp.1290-1298, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 5
  • Publication Date: 2021
  • Doi Number: 10.1002/elan.202060623
  • Journal Name: ELECTROANALYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.1290-1298
  • Keywords: Determination, etodolac, thiocolchicoside, voltammetry, anionic surfactant, PHARMACEUTICAL DOSAGE FORMS, HUMAN PLASMA, SQUARE-WAVE, HUMAN SERUM, NANOPARTICLES, OXIDATION, DRUG
  • Ankara University Affiliated: Yes

Abstract

In this study, a differential pulse voltammetry method was designed for the simultaneous determination of etodolac and thiocolchicoside in a tablet dosage form. This method is a sensitive, costless and reproducible one initially designed for the simultaneous determination of etodolac and thiocolchicoside using bare/unmodified glassy carbon electrode in the presence of sodium dodecyl sulfate. At optimized conditions, the method showed linear responses with etodolac and thiocolchicoside concentration in the range of 1 mu M to 80 mu M. The limits of detection and quantification were calculated as 0.11 mu M and 0.38 mu M for etodolac and 0.20 mu M and 0.67 mu M for thiocolchicoside, respectively.