Rapid and accurate simultaneous determination of fosinopril sodium and hydrochlorothiazide in tablets by HPLC

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Copy For Citation

Ozkan S. A., Akay C., Cevheroglu S., Senturk Z.

Journal of Liquid Chromatography and Related Technologies, vol.24, no.7, pp.983-991, 2001 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 24 Issue: 7
• Publication Date: 2001
• Doi Number: 10.1081/jlc-100103424
• Journal Name: Journal of Liquid Chromatography and Related Technologies
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.983-991
• Ankara University Affiliated: Yes

Abstract

A new, simple, precise, accurate, and rapid reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of fosinopril sodium and hydrochlorothiazide from tablets. The procedure is based on the use of the RP-HPLC method with a UV detector. Each analysis requires no longer than 6 minutes. A reversed phase C18 column with a mobile phase composed of a mixture of methanol: water (40:60, v/v), adjusted to pH 4 with 10% orthophosphoric acid, was used to separate both compounds with.