Electrochemical analysis of antipsychotics

KARADURMUŞ L., Kir D., KURBANOĞLU S., Ozkan S. A.

Current Pharmaceutical Analysis, cilt.15, sa.5, ss.413-428, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 15 Sayı: 5
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1573412914666180710114458
  • Dergi Adı: Current Pharmaceutical Analysis
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.413-428
  • Anahtar Kelimeler: Electroanalytical methods, antipsychotic agents, drug analysis, voltammetry, Schizophrenia, seizures, GLASSY-CARBON ELECTRODE, ADSORPTIVE STRIPPING VOLTAMMETRY, MODIFIED GOLD ELECTRODE, NANOTUBE PASTE ELECTRODE, ELECTROCATALYTIC DETERMINATION, PROMETHAZINE HYDROCHLORIDE, SENSITIVE DETERMINATION, HUMAN SERUM, ELECTROANALYTICAL CHARACTERISTICS, PHARMACEUTICAL FORMULATIONS
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2019 Bentham Science Publishers.Introduction: Schizophrenia is seizures accompanied by severe psychotic symptoms, and a steady state of continuation in the form of periods of stagnation. Antipsychotics are now the basis of treatment for schizophrenia and there is no other molecule that is antipsychotic priority in treatment. Antipsychotics can be classified into two groups; dopamine receptor antagonists such as promazine, fluphenazine etc. and serotonin-dopamine antagonists including risperidone, olanzapine, ziprasidone, aripiprazole etc. Materials and Methods: Electrochemical methods have been used for the determination of antipsychotic agent just as used in the determination of many drug agents. Nearly all of the antipsychotics are electroactive and can be analyzed by electrochemical methods. Electroanalytical methods offer generally high sensitivity, are compatible with modern techniques, have low cost, low requirements, and compact design. Among the most commonly used types, there are cyclic voltammetry, differential pulse voltammetry, square wave voltammetry and linear sweep voltammetry. Conclusion: The aim of this review is to evaluate the main line and the advantages and uses of electroanalytical methods that employed for the determination of antipsychotic medication agents used in schizophrenia. Moreover, applications of the methods to pharmaceutical analysis of Antipsychotics upto- date is also summarized in a table.