Objective: Today, the development of antibiotic resistance is increasing rapidly. This makes it necessary to discover new antibiotics; therefore, this research aims to find new antibacterial agents. Materials and Methods: Structures of the newly synthesised compounds (4a-d, 5a-d) were elucidated by elemental analyses and spectroscopic data. Their in vitro antibacterial activities were tested using a micro-dilution technique against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and Enterococcus faecalis. Ciprofloxacin was used as the control drug in this study, which was carried out in accordance with the guidelines of the European Committee on Antimicrobial Susceptibility Testing. Results: The antimicrobial activities of the compounds were found in a wide range with minimum inhibitory concentration (MIC) values of 15.62-125 μg/mL. Particularly, 4-((2-(2-(4-chloro-3-methyl)acetyl)hydrazineylidene)methyl)phenyl p-methyl benzenesulfonate (4b) was found to be most effective against Enterococcus faecalis with MIC value of 15.62 µg/mL. Conclusion: The findings of this study display that the different derivatives of the molecules in this study may be considered important candidates for future research. Considering the results, it is planned to reach more effective new compounds with modifications to be made by changing the substituents on the aromatic rings.