Akademik Veri Yönetim Sistemi
13th International Drug Chemistry Conference (13th DCC), Antalya, Türkiye, , Antalya, Türkiye, 6 - 09 Şubat 2025, ss.254
Flumethrin is a synthetic pyrethroid ectoparasiticide widely used in veterinary medicine. It is
also one of the acaricides used in beekeeping to control and treat Varroa mites. As a result,
flumethrin contaminates bee products, particularly beeswax. Like honey, beeswax is a threat
to human health. As it can be consumed in honey, consumption of food additives increases
human exposure through secondary routes, such as coatings in bakery products, capsules
and tablets, and surface treatments on certain fruits.1In this study, an electrochemical sensor
based on nanomaterial-supported molecularly imprinted polymers (MIPs) was developed
using the electropolymerization method. The sensor was formed on a glassy carbon electrode
(GCE) using 3-amino phenyl boronic acid (3-APBA) as a monomer by cyclic voltammetry. The
developed FLU/3-APBA@TiMXene/MIP-GCE sensor was characterized morphologically
(scanning electron microscopy) and electrochemically (electrochemical impedance
spectroscopy, cyclic voltammetry). To determine FLU, indirect measurement approach was
used via 5.0 mM [Fe(CN)6]3-/4- solution and the developed methodology was fully validated
according to the International Council of Harmonization guidelines. As a result of the
measurements, the linearity range of the developed sensor was found to be 10-100 pM and
the detection limit was found to be 1.97 pM.In addition, the selectivity of the sensor in the
presence of compounds with similar molecular structure and potentially interfering chemicals
was evaluated, and it was tested on honey by spiking the standard FLU to demonstrate the
applicability of the sensor in real matrix. Finally, the developed FLU/3-APBA@TiMXene/MIPGCE
sensor was successfully applied for the determination of FLU from the real honey
samples.
Acknowledgements: The authors gratefully acknowledge the support of Ankara University Research
Project Unit under the project number ADEP/TSA-2022-2632.