Some new bi- and ter-benzimidazole derivatives as topoisomerase I inhibitors

Alper S., ARPACI Ö., Şener Aki E., Yalçin I.

Farmaco, vol.58, no.7, pp.497-507, 2003 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 7
  • Publication Date: 2003
  • Doi Number: 10.1016/s0014-827x(03)00042-9
  • Journal Name: Farmaco
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, International Pharmaceutical Abstracts
  • Page Numbers: pp.497-507
  • Keywords: Benzimidazoles, Inhibitors, Topoisomerase I
  • Ankara University Affiliated: Yes

Abstract

The discovery of DNA topoisomerases has added a new dimension to the study of anticancer drugs. In the last years detailed investigation of bi- and ter-benzimidazole derivatives revealed that these compounds are a new class of topoisomerase I inhibitors that poisons mammalian topoisomerase I. In this context a survey about topoisomerase I poisoning activity and cytotoxicity of bi- and ter-benzimidazoles is given. Moreover some recent results about new derivatives, some structure-activity relationships and comparison of activity of various functional groups are discussed. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.