Syntheses of novel indole lipoic acid derivatives and their antioxidant effects on lipid peroxidation

Gurkan A. S., Karabay A. Z., Buyukbingol Z., Adejare A., Buyukbingol E.

ARCHIV DER PHARMAZIE, no.2-3, pp.67-73, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2005
  • Doi Number: 10.1002/ardp.200400932
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.67-73
  • Keywords: alpha-lipoic acid, indole, lipid peroxidation, antioxidant, MELATONIN RECEPTOR, SYSTEM
  • Ankara University Affiliated: Yes

Abstract

The aim of the study was to examine antioxidant properties of conjugates based on indole and lipoic acid moieties. The design and syntheses of novel indole alpha-lipoic acid derivatives were performed. The antioxidant properties of target compounds were investigated using rat liver microsomal, NADPH-dependent lipid peroxidation inhibition. Some of the target compounds, especially those containing amide linker at position 5 of indole ring, proved to be highly effective in inhibiting lipid peroxidation as compared to alpha-lipoic acid.