Developmentand Validation of an In Vitro Dissolution Method Based on HPLC Analysis For L-Dopa Release From PLGA Nanoparticles

ARISOY S., Sayiner O., ÇOMOĞLU T.

BEZMIALEM SCIENCE, vol.9, no.1, pp.9-19, 2021 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.14235/bas.galenos.2020.3860
  • Journal Name: BEZMIALEM SCIENCE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.9-19
  • Keywords: Analytical validation, L-Dopa, PLGA nanoparticles, in nitro drug release, sample and scperation method, dialysis membrane method, LEVODOPA, QUANTIFICATION, CARBIDOPA, DELIVERY
  • Ankara University Affiliated: Yes

Abstract

Objective: In the past decade, dissolution testing has emerged as a valauble tool for the characterization of drug product performance in the field of pharmaceuticals. During the development of new formulations, dissolutions tests assist in the evaulation of any changes in the formulation arising during manufacturing process, thereby assuring product quality and performance post manufacturing.