Nanocarriers for Effective Brain Drug Delivery

ÇOMOĞLU T., ARISOY S., Akkus Z. B.

CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol.17, no.13, pp.1490-1506, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 17 Issue: 13
  • Publication Date: 2017
  • Doi Number: 10.2174/1568026616666161222101355
  • Journal Name: CURRENT TOPICS IN MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1490-1506
  • Keywords: Blood-brain barrier, Brain drug delivery, Chemical structures of nanocarriers, Nanosized drug delivery systems, Particle size, Surface charge, Surface coating agents, Targeting ligands., SOLID LIPID NANOPARTICLES, CNS MICROVASCULAR PERICYTE, CENTRAL-NERVOUS-SYSTEM, PEG-PLA NANOPARTICLES, PLGA NANOPARTICLES, POLYMERIC NANOPARTICLES, GOLD NANOPARTICLES, TARGETED DELIVERY, IN-VITRO, CHITOSAN NANOPARTICLES
  • Ankara University Affiliated: Yes

Abstract

Drug delivery to the brain is an engaged research topic in the field of nanomedicine. The passage of therapeutics into the brain parenchyma is more complicated than other body tissues due to it is limited by restrict barrier structure called blood-brain barrier (BBB). Nanotechnology holds great promise to overcome the BBB and thereby enable treatment of neurodegenerative diseases. Nanocarriers have been investigated several times as effective brain drug delivery systems in the past few decades.