Effects of<i> PDYN</i> 68-bpVNTR,<i> BDNF</i> rs6265,<i> OPRD1</i> rs569356 and<i> OPRM1</i> rs2075572 polymorphisms on opioid-methamphetamine co-use

Ak M., Ozer-Uzaldi G., Yildirim M. A., Ozkan-Kotiloglu S., Danisman M., AKYÜZLÜ D.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, cilt.116, 2025 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 116
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.etap.2025.104714
  • Dergi Adı: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Environment Index, Greenfile, MEDLINE, Pollution Abstracts, Veterinary Science Database
  • Ankara Üniversitesi Adresli: Evet

Özet

To investigate the impact of PDYN 68-bpVNTR, BDNF rs6265, OPRD1 rs569356 and OPRM1 rs2075572 variations on the susceptibility to opioid-methamphetamine co-use, a total of 532 individuals, including opioid (n =104), and methamphetamine (n = 166) users as well as opioid and methamphetamine co- users (n =158) and healthy individuals (n =104), were included. BDNF rs6265, OPRD1 rs569356 and OPRM1 rs2075572 were genotyped by PCR-RFLP method, while PDYN 68-bp VNTR was genotyped by PCR. The assessment of impulsiveness, craving, withdrawal, anxiety and depressive symptoms was conducted using scales. A significant difference was identified between the substance-using groups and the control group in view of the alleles of PDYN 68-bp VNTR (p = 0.001). The allele frequencies of the PDYN 68-bp VNTR exhibited a difference between opioid and methamphetamine users (p = 0.018). The 5-repeat allele was first observed in the Turkish population. The analysed polymorphisms could contribute to the development of addiction, exerting an influence on impulsiveness, craving and withdrawal.