Effects of clomiphene citrate on ovulation, implantation, fetal growth and chromosomes in mice

DÖKMECİ F., TEKŞEN A. F., BİLGİLİ A., Izgur H., Sayli B., KURTAY G.

Turkish Journal of Medical Sciences, vol.26, no.6, pp.537-541, 1996 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 6
  • Publication Date: 1996
  • Journal Name: Turkish Journal of Medical Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.537-541
  • Keywords: chromosomes, clomiphene citrate, fetal outcome, implantation rate, mice, ovulation
  • Ankara University Affiliated: Yes

Abstract

Effects of clomiphene citrate (CC) doses 2.5 and 5 μg/gr body weight on ovulation, implantation rate, fetal outcome and chromosomes of 120 female mice were evaluated in this study. No structural and/or numerical chromosomal aberrations and morphological abnormality of the newborn mice were observed in both doses. CC, administered on the mating and the consecutive days completely inhibited the gestation while implantation rates and number of newborns decreased significantly as the dose increased. However we did not observe any adverse effect of CC on fetal growth and development.