Cytochrome P450 1B1∗2 gene polymorphism in a cturkish population

Kargin Solmaz F. O., ADA A. O.

Fabad Journal of Pharmaceutical Sciences, vol.44, no.3, pp.215-218, 2019 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 3
  • Publication Date: 2019
  • Journal Name: Fabad Journal of Pharmaceutical Sciences
  • Journal Indexes: Scopus
  • Page Numbers: pp.215-218
  • Keywords: CYP1B1, Cytochrome P450, Genetic polymorphism, Rs10012, Rs1056827, Turkish population
  • Ankara University Affiliated: Yes


© 2019 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.The polymorphisms in genes encoding xenobiotic metabolising enzymes may be important in the individual susceptibility to various diseases including cancer due to the altered metabolism of carcinogens. Cytochrome P450 1B1 (CYP1B1) is an important enzyme of CYP superfamily and is involved in the formation of reactive estrogen metabolites as well as in the activation of environmental carcinogens. CYP1B1∗2 variant of CYP1B1 gene has two linked polymorphisms, m1 and m2, resulting in Arg48Gly and Ala119Ser amino acid substitutions respectively. In this study, CYP1B1∗2 m1 (rs10012) and m2 (rs1056827) polymorphisms were determined among 150 healthy individuals of a Turkish population by allele specific polymerase chain reaction (PCR) method and the results were compared with various populations. The frequency of CYP1B1∗1/∗1 (wild type), CYP1B1∗1/∗2 (heterozygous) and, CYP1B1∗2/∗2 (mutant) genotypes were found 47.3%, 44.7% and 8.0% respectively. The genotype frequencies were compared with previous studies conducted on diferent populations. The results show that the genotype frequencies of the CYP1B1∗2 gene polymorphism in a Turkish population are similar to other Caucasian populations.