Serum leukemia inhibitory factor (LIF) levels in patients with Takayasu's and Giant cell arteritis: A cross-sectional study Niveles séricos del factor inhibidor de la leucemia en pacientes con arteritis de Takayasu y de células gigantes, un estudio transversal


Aksoy R., TURGAY T. M., YILMAZ R., SEZER S., YAYLA M. E., USLU E.

Reumatologia Clinica, 2024 (ESCI) identifier

  • Publication Type: Article / Article
  • Publication Date: 2024
  • Doi Number: 10.1016/j.reuma.2024.02.005
  • Journal Name: Reumatologia Clinica
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, MEDLINE, DIALNET
  • Keywords: Giant cell arteritis, Leukemia inhibitory factor, Takayasu's arteritis
  • Ankara University Affiliated: Yes

Abstract

Introduction and objectives: In this study, we aimed to evaluate LIF levels and its possible relationship with disease activity in patients with Takayasu's (TAK) and Giant cell arteritis (GCA) patients. Materials and methods: 23 Takayasu's arteritis, 9 Giant cell arteritis patients and 25 healthy volunteers were included in the study. Serum LIF levels were measured ELISA. Results: The mean age of Giant cell arteritis patients was statistically significantly higher than the other groups (p < 0.001). The rate of women was found to be higher in Takayasu's arteritis (p = 0.021). When healthy control, patients with GCA and Takayasu arteritis were compared, there was a difference in LIF values (p = 0.018). In subgroup analyzes, LIF values were found to be higher in GCA patients compared to healthy controls (p < 0.05). There was no statistically significant correlation between LIF and CRP (Rho = −0.038, p = 0.778), ESR (Rho = 0.114, p = 0.399) and ITAS (Rho = −0.357, p = 0.094). While CRP was statistically significantly higher in patients with disease activity (p = 0.003), there was no statistically significant difference between patients in terms of ESR and LIF values. While there was a statistically significant relationship between CRP (OR = 1.19 [1.03–1.37], p = 0.018) and disease activity in univariate analyses, no statistically significant variable was found in multivariable analyses. Conclusions: LIF values were significantly higher in patients with Giant cell arteritis compared to healthy controls.