Synthesis and Evaluation of Antioxidant Properties of Novel 2-[2-(4-chlorophenyl) benzimidazole-1-yl]-N-(2-arylmethylene amino) acetamides and 2-[2-(4-chlorophenyl) benzimidazole-1-yl]-N-(4-oxo-2-aryl-thiazolidine-3-yl) acetamides-I

KILCIGİL G., Gurkan S., ÇOBAN T., ÖZDAMAR E. D., EKE B.

CHEMICAL BIOLOGY & DRUG DESIGN, vol.79, no.5, pp.869-877, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Letter
  • Volume: 79 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.1111/j.1747-0285.2012.01347.x
  • Journal Name: CHEMICAL BIOLOGY & DRUG DESIGN
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.869-877
  • Keywords: antioxidant activity, benzimidazole, methyleneamino acetamide, thiazolidine, LIPID PEROXIDE FORMATION, BENZIMIDAZOLE DERIVATIVES, FREE-RADICALS, AGENTS, CAPACITIES, TISSUES, LIVER
  • Ankara University Affiliated: Yes

Abstract

Our approach was to synthesize and examine the antioxidant properties of some new 2-[2-(4-chlorophenyl)benzimidazole-1-yl]-N-(2-arylmethyleneamino) acetamide (118) and 2-[2-(4-chlorophenyl)benzimidazole-1-yl]-N-(4-oxo-2-aryl-thiazolidine-3-yl)acetamide (1t18t) derivatives. Their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation levels (LP assay) and microsomal ethoxyresorufin O-deethylase activities (EROD assay) were determined. The free radical scavenging properties of the compounds were also examined in vitro determining the interaction of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical. The compounds showed significant effects in the above tests.