Impact of TNF-alpha and IL-6 levels on development of cachexia in newly diagnosed NSCLC patients

KAYACAN O., Karnak D., Beder S., Gullu E., Tutkak H., Senler F., ...More

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, vol.29, no.4, pp.328-335, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 4
  • Publication Date: 2006
  • Doi Number: 10.1097/01.coc.0000221300.72657.e0
  • Journal Name: AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.328-335
  • Keywords: cachexia, cytokines, IL-6, lung cancer, TNF-alpha, CELL LUNG-CANCER, TUMOR-BEARING MICE, MEGESTROL-ACETATE, MEDROXYPROGESTERONE ACETATE, SERUM INTERLEUKIN-6, CYTOKINE LEVELS, WEIGHT, PROTEIN, ADENOCARCINOMA, CHOLESTEROL
  • Ankara University Affiliated: Yes

Abstract

Objectives: We investigated the role of cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in cachexia development in newly diagnosed nonsmall cell lung cancer (NSCLC) patients. Methods: We evaluated 44 (M/F:41/3) NSCLC patients and 12 (M/F:10/2) age matched healthy smokers. NSCLC cases with a weight loss of >= 10% consisted the cachectic group (n:23, M/F:21/2) and the ones with < 10% weight loss consisted the noncachectic group (n:21, M/f:19/2).