Synthesis of some new benzimidazolecarboxamides and evaluation of their antimicrobial activity

Göker A. H., Tuncbilek M., Ayhan G., Altanlar N.

FARMACO, vol.53, no.6, pp.415-420, 1998 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 6
  • Publication Date: 1998
  • Doi Number: 10.1016/s0014-827x(98)00045-7
  • Journal Name: FARMACO
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Index Chemicus (IC)
  • Page Numbers: pp.415-420
  • Keywords: benzimidazolecarboxamides, antimicrobial activity
  • Ankara University Affiliated: Yes

Abstract

A series of 1,2-disubstituted benzimidazole-5(6)-carboxamides was prepared and evaluated in vitro for antimicrobial activity against Staphyloccus aureus, Escherichia coli and Candida albicans. The precursor benzimidazolecarboxylic acids 4a-c and 9a-c were prepared via oxidative condensation of diaminobenzoic acids with aldehydes and via several steps over the 2(1H)-benzimidazolones, respectively. All acids were converted to their acyl chlorides with SOCI2, then amidified with several N,N'-dialkylaminoethyl derivatives. Compounds 8a-c, 20 and 22 exhibited the best activity. (C) 1998 Elsevier Science S.A. All rights reserved.