Akademik Veri Yönetim Sistemi
Rheumatology, cilt.65, sa.1, 2026 (SCI-Expanded, Scopus)
Objectives: SLE is a heterogeneous autoimmune disorder often complicated by vascular events, with or without antiphospholipid antibody syndrome (APS). This study aimed to explore subclinical venous involvement in SLE using biochemical and imaging modalities, focusing on vein wall thickness (VWT) and inflammation-related biomarkers. Methods: In this cross-sectional study, 68 SLE patients were categorized based on antiphospholipid antibody (APA) status and clinical APS. Results: were compared with 22 RA patients and 20 healthy controls. Serum levels of P-selectin, growth differentiation factor 15 (GDF15) and citrullinated histone 3 (CH3) were measured using ELISA. Ultrasonographic assessments evaluated VWT at bilateral jugular veins, femoral veins, portal vein and femoral artery. Correlations and predictors of vascular changes were analysed statistically. Results VWT was significantly increased in SLE patients compared with both the control groups (P<0.001), regardless of APA and APS status. Serum P-selectin, GDF15 and CH3 levels were elevated in SLE-APS patients. GDF15 levels correlated positively with VWT, and increased portal VWT was independently associated with thrombosis. Biomarkers showed significant associations with APS, suggesting their role as indicators of prothrombotic states. No significant associations were found between vascular parameters and disease activity score. Conclusion: Subclinical venous involvement appears to be a novel vascular feature of SLE, reflected by increased VWT and its association with thrombosis and biomarkers. Increased portal vein thickness may indicate vascular risk. Whether these changes result from inflammation or vascular remodelling remains unclear, but their presence irrespective of disease activity highlights their clinical relevance.