Akademik Veri Yönetim Sistemi
44th World Chemistry Congress UIPAC, İstanbul, Türkiye, 11 - 16 Ağustos 2013
The petroleum oil has an
important place within the chemical industries as a natural energy sources. However, due to the fact that it’s a non-renewable resource, there is a demand for the utilization of
alternative resources for the replacement of petroleum-based chemicals. Therefore,
nowadays it is crucial to utilize renewable raw-materials (e.g. glycerol) to
obtain value-added chemicals [1]. One-pot syntheses of heterocyclic compounds such as pyridine and
quinoline derivatives using a renewable chemical, glycerol, have been
investigated by microwave-assisted reactions. In the first step of our research, thermal conversion of glycerol has
been studied under microwave heating with different ammonia source compounds
((NH4)2HPO4, (NH4)2SO4, NH4Cl etc.) in acidic medium [2,5]. In these reactions, a mixture of mainly 3-methylpyridine and pyridine,
including ethylpyridine and ethyl,methylpyridine has been successfully obtained
in one-pot synthesis. In
order to improve the yields of pyridine derivatives, optimization studies were
performed. In the presence of acetic acid, it was observed that the product
yields were increased up to 70%. Glycerol was also reacted with various aniline
derivatives using microwave energy in accordance with the known Skraup
synthesis conditions. Different quinoline derivatives were synthesized
successfully by the reaction of glycerol with aniline derivatives [3,4,5]. All
new compounds were identified using data obtained from FTIR, HPLC, GC-MS and 1HNMR analysis.