Antioxidant properties of flavone-6(4′)-carboxaldehyde oxime ether derivatives

KILCIGİL G., Coban T., Tuncbilek M., Can-Eke B., Bozdag-Dundar O., Ertan R., ...More

Archives of Pharmacal Research, vol.27, no.6, pp.610-614, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 6
  • Publication Date: 2004
  • Doi Number: 10.1007/bf02980158
  • Journal Name: Archives of Pharmacal Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.610-614
  • Keywords: flavone, oxime ether, lipid peroxidation, superoxide dismutase, DPPH, antioxidant, LIPID PEROXIDE FORMATION, ANTIMICROBIAL ACTIVITY, FREE-RADICALS, GUINEA-PIG, FLAVONOIDS, INHIBITORS, MECHANISMS, OXIDASE, LIVER
  • Ankara University Affiliated: Yes

Abstract

The in vitro antioxidant properties of some flavone-6(4)-carboxaldehyde oxime ether derivatives (Ia-f, IIa-f) were determined by their effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels by measuring the formation of 2-thiobarbituric acid reactive substances. The free radical scavenging properties of the compounds were also examined in vitro by determining their capacity to scavenge superoxide anions and interact with the stable free radical 2, 2-diphenyl-1-picrylhydrazyl (DPPH). The most active compounds, IIb (Flavone-4′-carboxaldehyde-O-ethyl oxime) and Id (Flavone-6-carboxaldehyde-O-[2-(1-pyrolidino) ethyl] oxime), caused 98 and 79% inhibition of superoxide anion production and DPPH stable free radical at 10-3 M, respectively.