Voltammetric determination of salbutamol based on electrochemical oxidation at platinum and glassy carbon electrodes

Yilmaz N., Ozkan S. A., Uslu B., Senturk Z., Biryol I.

Turkish Journal of Chemistry, vol.22, no.2, pp.175-182, 1998 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 2
  • Publication Date: 1998
  • Journal Name: Turkish Journal of Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.175-182
  • Keywords: salbutamol, platinum and glassy carbon electrodes, pharmaceutical dosage forms, voltammetry, SPECTROPHOTOMETRIC METHOD, LIQUID-CHROMATOGRAPHY, GAS-CHROMATOGRAPHY, HUMAN PLASMA, SULFATE, DRUGS, ALBUTEROL, COLUMNS, URINE
  • Ankara University Affiliated: Yes

Abstract

The oxidative behavior of salbutamol was studied as a function of pH at platinum and activated glassy carbon electrodes. Between pH 1.9 and 12.0, the drug was characterized by a single oxidation step at both electrodes. The process was found to be dependent on the nature and the pH of the supporting elctrolyte. The procedure yielded a linear concentration range of 1 × 10-4 to 1 × 10-3 M and 2 × 10-5 to 1 × 10-3 M in 0.2 M sulphuric acid and a phosphate buffer of pH 6, at platinum and glassy carbon electrodes, respectively. The method was used for the determination of salbutamol in pharmaceutical dosage forms.