DNA Copy Number Changes in Gastric Adenocarcinomas: High Resolution-Comparative Genomic Hybridization Study in Turkey

GÜMÜŞ AKAY G., ÜNAL A. E., ELHAN A. H., BAYAR S., Karadayt K., SUNGUROĞLU A., ...More

ARCHIVES OF MEDICAL RESEARCH, vol.40, no.7, pp.551-560, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 7
  • Publication Date: 2009
  • Doi Number: 10.1016/j.arcmed.2009.07.004
  • Journal Name: ARCHIVES OF MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.551-560
  • Keywords: Genomic imbalances, High-resolution-comparative genomic hybridization, Gastric adenocarcinoma, Tumor progression, GENETIC ALTERATIONS, HISTOLOGIC SUBTYPES, PRECURSOR LESIONS, TUMOR PROGRESSION, POOR-PROGNOSIS, CELL-LINES, CANCER, EXPRESSION, CARCINOMA, RCAS1
  • Ankara University Affiliated: Yes

Abstract

Background and Aims. Multiple genetic alterations are responsible for development and progression of gastric cancer which is one of the leading causes of cancer-related deaths worldwide. The aim of this study was to identify the genomic imbalances of gains and/or losses in gastric adenocarcinomas from Turkish patients and to investigate their association with development and progression of this type of cancer.