POLYMORPHISM IN THE P2X7 GENE INCREASES SUSCEPTIBILITY TO EXTRAPULMONARY TUBERCULOSIS IN TURKISH CHILDREN

TEKİN D., Kayaalti Z., Dalgic N., Cakir E., Soylemezoglu T., Kutlubay B. I., ...Daha Fazla

PEDIATRIC INFECTIOUS DISEASE JOURNAL, cilt.29, sa.8, ss.779-782, 2010 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 8
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1097/inf.0b013e3181d9932e
  • Dergi Adı: PEDIATRIC INFECTIOUS DISEASE JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.779-782
  • Anahtar Kelimeler: childhood, extrapulmonary tuberculosis, single nucleotide polymorphism, P2X(7) GENE, RECEPTOR, PROTEIN
  • Ankara Üniversitesi Adresli: Evet

Özet

The P2X7 gene polymorphisms have been linked to increased risk for pulmonary and extrapulmonary tuberculosis in some populations. In this study, the genotype and allelic frequencies 1513A -> C variant within the P2X7 gene was significantly higher than in the healthy controls (P = 0.035, P = 0.041). This is the first study demonstrating that the 1513A -> C polymorphism is associated with extrapulmonary tuberculosis in children.