Short-duration mechanical ventilation enhances diaphragmatic resistance but impairs fatigue force production

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Shanely R., Coombes J., ZERGEROĞLU A. M., Webb A., Powers S.

CHEST, vol.123, no.1, pp.195-201, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 123 Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.1378/chest.123.1.195
  • Journal Name: CHEST
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.195-201
  • Keywords: fiber type, muscular endurance, respiratory muscles, SKELETAL-MUSCLE, CONTRACTILE PROPERTIES, RESPIRATORY MUSCLES, RAT DIAPHRAGM, IN-VITRO
  • Ankara University Affiliated: No

Abstract

Study objectives: Mechanical ventilation (MV) is a life-support measure for patients who cannot maintain adequate alveolar ventilation. Following prolonged MV, difficulty in weaning patients from the ventilator can occur, and it has been postulated that difficult weaning is linked to respiratory muscle dysfunction. We tested the hypothesis that IS h of controlled MV will diminish diaphragmatic maximal tetanic specific tension (force per cross-sectional area of muscle) without impairing diaphragmatic fatigue resistance.