Electrochemical behavior of vardenafil on glassy carbon electrode: Determination in tablets and human serum

Uslu B., Dogan B., Ozkan S. A., Aboul-Enein H.

Analytica Chimica Acta, vol.552, no.1-2, pp.127-134, 2005 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 552 Issue: 1-2
  • Publication Date: 2005
  • Doi Number: 10.1016/j.aca.2005.07.040
  • Journal Name: Analytica Chimica Acta
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.127-134
  • Keywords: vardenafil hydrochloride, voltammetry, drug analysis, oxidation mechanism, ERECTILE DYSFUNCTION, DIFFERENTIAL-PULSE, SQUARE-WAVE, VOLTAMMETRY, SILDENAFIL, PHARMACEUTICALS, IONIZATION
  • Ankara University Affiliated: Yes

Abstract

The voltammetric behavior of vardenafil was studied on glassy carbon electrode using cyclic, differential pulse (DPV) and Osteryoung square-wave (OSW) voltammetric techniques. Vardenafil exhibited irreversible anodic waves over the pH range 1.00-12.00 in different supporting electrolytes. The current-concentration plot was rectilinear over the range from 4 × 10 -7 to 2 × 10-5 M with correlation coefficient of 0.999. The wave was characterized as being irreversible and diffusion- controlled. The developed procedure was successfully applied to the determination of vardenafil in tablets and in spiked human serum. Furthermore, results obtained by the proposed method have been compared with high-performance liquid chromatographic method. © 2005 Elsevier B.V. All rights reserved.