Contribution to the alkaline degradation of cefepime

Uslu B., Ozkan S. A., Zuman P.

Microchemical Journal, vol.76, no.1-2, pp.61-63, 2004 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 76 Issue: 1-2
  • Publication Date: 2004
  • Doi Number: 10.1016/j.microc.2003.10.011
  • Journal Name: Microchemical Journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.61-63
  • Keywords: antibiotic cefepime, alkaline degradation, UV-spectra, kinetics, voltammetric reductions
  • Ankara University Affiliated: Yes

Abstract

Deviations of the value of the rate constant for borate anions of the first step in the degradation of the antibiotic cefepime from Bronsted relation and deviations from i=f(pH) plots in voltammetric reductions of the oximino group led to investigation of the kinetics of degradation of cefepime in ammonia, borate, CHES and glycine buffers pH 9.3 using UV-visible spectra. Presence of at least two consecutive processes was detected and an interaction of cefepime with glycine has been proved. Identification of intermediates is under investigation. © 2003 Elsevier B.V. All rights reserved.