Akademik Veri Yönetim Sistemi
REVUE ROUMAINE DE CHIMIE, cilt.60, sa.5-6, ss.467-475, 2015 (SCI-Expanded)
The kinetics and mechanism for electrochemical oxidation of Nilotinib, a tyrosine kinase inhibitor drug, used in the treatment of chronic myelogenous leukemia, were studied using cyclic and differential pulse voltammetric methods on glassy carbon electrode. The pH-dependent oxidation of Nilotinib was studied within the range of pH 0.3-10.0. Two well-defined peaks were observed, 1.09 V, and 1.44 V (versus Ag/AgCl) in phosphate buffer at pH 2.0 by differential pulse voltammetry. The irreversible and mixed diffusion-adsorption controlled electrochemical oxidation of Nilotinib was revealed by studies at different scan rates. The rate constant, surface coverage coefficients of adsorbed molecules and the number of electrons transferred in electrode mechanisms were calculated. The mechanism was evaluated with model compounds having the diphenylamine moiety and acetamide group in their structure. The oxidation processes for two anodic peaks were found to be two-electron transfers.