Polymorphisms and Protein Expressions of Glutathione S-Transferase M1 and T1 in Non-Small Cell Lung Cancer

KILIÇ M., ADA A. O., OĞUZTÜZÜN S., Demirag F., ÇELİK S., Bicakcioglu P., ...More

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.14, no.3, pp.237-242, 2017 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.4274/tjps.74745
  • Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.237-242
  • Keywords: GSTM1, GSTT1, polymorphism, protein expression, non-small cell lung carcinoma, GSTP1 POLYMORPHISMS, TURKISH POPULATION, RISK, GENOTYPE, GSTM1, GSTT1, CYTOCHROME-P450, ASSOCIATION, METABOLISM, TUMOR
  • Ankara University Affiliated: Yes

Abstract

Objectives: The deletion polymorphisms of glutathione S-transferase (GST) GSTM1 and GSTT1 genes result in the absence of the corresponding protein, which decreases the detoxification of carcinogens. Studies evaluating polymorphisms and protein expressions in the same patients are limited. Therefore, in this study, we aimed to investigate the association between polymorphisms and protein expressions of GSTM1 and GSTT1 in lung tissues of patients with non-small cell lung cancer (NSCLC).