Apoptotic Effects of Some Tetrahydronaphthalene Derivatives on K562 Human Chronic Myelogenous Leukemia Cell Line

KOÇ A., ÖZKAN T., Hekmatshoar Y., Gurkan-Alp A. S., AKTAN F., Buyukbingol Z., ...More

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.17, no.14, pp.1924-1930, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 14
  • Publication Date: 2017
  • Doi Number: 10.2174/1871521409666170412122811
  • Journal Name: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1924-1930
  • Keywords: Retinoids, chronic myelogenous leukemia, apoptosis, cancer, K562, tetrahydronaphthalene, CHRONIC MYELOID-LEUKEMIA, TRANS-RETINOIC ACID, BREAST-CANCER CELLS, SUCCINATE-INDUCED APOPTOSIS, TYROSINE KINASE INHIBITORS, FERULIC ACID, DEATH, PROLIFERATION, RESISTANCE, THERAPY
  • Ankara University Affiliated: Yes

Abstract

Background: Retinoids which are vitamin A (Retinol) derivatives have been suggested to mediate the inhibition of cancer cell growth and apoptosis. It has been reported that all trans retinoic acid (ATRA) exhibited suppressive effects on different types of leukemia including chronic myelogenous leukemia.