Evaluation of the genotoxic effects of patients undergoing hyperbaric oxygen (HBO) therapy Hiperbarik oksijen tedavisinin (HBOT) sebep olduǧu genotoksik etkilerin İncelenmesi

ÜSTÜNDAĞ A., Şimşek K., Ay H., Dündar K., SÜZEN H. S., Aydin A., ...Daha Fazla

Turkish Journal of Pharmaceutical Sciences, cilt.11, sa.2, ss.203-208, 2014 (SCI-Expanded, Scopus, TRDizin) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 2
  • Basım Tarihi: 2014
  • Dergi Adı: Turkish Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.203-208
  • Anahtar Kelimeler: Genotoxicity, Hyperbaric oxygen therapy, Micronucleus test
  • Ankara Üniversitesi Adresli: Evet

Özet

Hyperbaric oxygen (HBO) therapy is successfully applied for a wide variety of diseases. However, recent studies in humans undergoing hyperbaric oxygen (HBO) therapy have revealed that HBO is able to induce genotoxic effects especially in lymphocytes while the biological significance of this outcome is still not clear. HBO mediated genotoxicity in lymphocytes has been determined by using the in vitro Cytokinesis Block Micronucleus (MN) test in patients undergoing HBO therapy. Blood samples were obtained from 100 voluntary patients and were drawn by venipuncture before and immediately after the first session of HBO treatment. MN frequencies were significantly increased after the first session of HBO treatment. According to the MN test results, it is observed that HBO treatment can increase the clastogenic effects.