Effects of compression speed and lubrication on the compaction properties of some commonly used direct compression materials Basım Hızının ve Lubrikant Etkisinin Bazı Direkt Basım Ajanlarının Basım Özellikleri Üzerine Etkileri


Turkish Journal of Pharmaceutical Sciences, vol.7, no.2, pp.127-138, 2010 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 2
  • Publication Date: 2010
  • Journal Name: Turkish Journal of Pharmaceutical Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.127-138
  • Keywords: Avicel PH 101, Compression speed, Fujicalin, Lubrication, Starch 1500
  • Ankara University Affiliated: Yes


The purpose of this study was to investigate the effects of punch speed and lubrication (with and without the addition of 1% magnesium stearate) on the compaction properties of some commonly used commercial direct compression agents. The compressibility of these materials was analyzed using compression parameters derived from the Heckel equation. Three different classes of excipients having plastic, elastic and brittle fragmentation characteristics were evaluated, including microcrystalline cellulose (Avicel PH 101), pregelatinized starch (Starch 1500) and dibasic calcium phosphate (Fujicalin). Tablets were prepared using a compaction simulator under 20 kN force with a flat-faced 11mm punch Three different speeds were investigated 10 50 and 100 mm/sec Data demonstrated that plastic materials like Avicel PH 101 form harder tablets at low compression speeds whereas brittle fragmenting materials like Fujicalin were relatively unaffected by comnaction speed. Avicel PH 101 gave the hardest tablets at all compression speeds with and without the addition of lubricant.