Electrooxidation of the antiviral drug valacyclovir and its square-wave and differential pulse voltammetric determination in pharmaceuticals and human biological fluids

Uslu B., Ozkan S. A., Senturk Z.

Analytica Chimica Acta, vol.555, no.2, pp.341-347, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Abstract
  • Volume: 555 Issue: 2
  • Publication Date: 2006
  • Doi Number: 10.1016/j.aca.2005.09.034
  • Journal Name: Analytica Chimica Acta
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.341-347
  • Keywords: valacyclovir, cyclic voltammetry, differential pulse voltammetry, square-wave voltammetry, glassy carbon electrode, tablet, biological fluids, ELECTROCHEMICAL OXIDATION, HUMAN SERUM, ACYCLOVIR, GUANINE, VALACICLOVIR, ADENINE
  • Ankara University Affiliated: Yes

Abstract

The electrochemical properties of valacyclovir, an antiviral drug, were investigated in pH range 1.8-12.0 by cyclic, differential pulse and square-wave voltammetry. The drug was irreversibly oxidized at a glassy carbon electrode in one or two oxidation steps, which are pH-dependent. For analytical purposes, a very resolved diffusion controlled voltammetric peak was obtained in Britton-Robinson buffer at pH 10.0 using differential pulse and square-wave modes. Limits of detection were 1.04 × 10-7 and 4.60 × 10-8 M for differential pulse and square-wave voltammetry, respectively. The applicability to direct assays of tablets, spiked human serum and simulated gastric fluid, was described. © 2005 Elsevier B.V. All rights reserved.