Synthesis and cytotoxic activity of platinum(II) and platinum(IV) complexes with 2-hydroxymethylbenzimidazole or 5(6)-chloro-2-hydroxymethylbenzimidazole ligands against MCF-7 and HeLa cell lines

Utku S., Guemues F., Guer S., Oezkul A.

TURKISH JOURNAL OF CHEMISTRY, vol.31, no.4, pp.503-514, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 4
  • Publication Date: 2007
  • Journal Name: TURKISH JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.503-514
  • Keywords: benzimidazole, cytotoxic activity, HeLa cell line, MCF-7 cell line, platinum(IV) complexes, platinum(II) complexes, DNA, CISPLATIN, RESISTANCE
  • Ankara University Affiliated: Yes

Abstract

Four platinum(II) and 4 platinum(IV) complexes with the structures [PtL2Cl2], [PtL2I2], [PtL2Cl4], and [ PtL2Cl2( OH)(2)] ( L = 5(6)-non/orchloro-substituted-2-hydroxymethylbenzimidazole ligands as "non-leaving groups"), respectively, were synthesized and characterized by their elemental analyses, and IR and H-1-NMR spectra. In vitro cytotoxic activities of the platinum( II) and platinum( IV) complexes were tested against the human MCF-7 ( breast cancer) and HeLa ( cervix cancer) cell lines using the cell culture method. In general, the platinum( II) complexes were more active than the corresponding platinum( IV) complexes. The complexes, which were found to be less active than cisplatin, exhibited cyctotoxicity comparable to carboplatin on the human MCF-7 and HeLa cell lines.