Development and In Vitro Evaluation of Nifedipine Gel Formulations for Anorectal Applications

Bagci N., SEZGİN BAYINDIR Z., İNAL Ö., ALTANLAR N., YÜKSEL N.

CURRENT DRUG DELIVERY, vol.17, no.2, pp.126-139, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.2174/1567201817666200102125242
  • Journal Name: CURRENT DRUG DELIVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.126-139
  • Keywords: Nifedipine, anal fissure, anorectal gel, texture analysis, rheology, freeze-thaw cycle, CHRONIC ANAL-FISSURE, MUCOADHESIVE PROPERTIES, TOPICAL DILTIAZEM, SOLUBILITY, DESIGN
  • Ankara University Affiliated: Yes

Abstract

Objective: Current study focuses on the formulation and characterization of lipophilic and hydrophilic gel formulations of nifedipine to treat anal fissure via anodermal application.