An electrochemical sensor based on carbon nanofiber and molecular imprinting strategy for dasatinib recognition

Yıldız E., Cetinkaya A., Çorman M. E., Atici E. B., UZUN L., ÖZKAN S. A.

Bioelectrochemistry, vol.158, 2024 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 158
  • Publication Date: 2024
  • Doi Number: 10.1016/j.bioelechem.2024.108701
  • Journal Name: Bioelectrochemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Compendex, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Carbon nanofiber, Dasatinib, Molecularly imprinted polymer, Pseudo-specific monomer
  • Ankara University Affiliated: Yes

Abstract

Herein, we proposed a new approach to design a MIP-based electrochemical sensor with carbon nanofiber (CNF), which could improve its conductivities as well as electrode sensitivity and successful detection of dasatinib (DAS). CNFs are capable of forming high porosity with significant interconnected porous networks. The poly(2-hydroxyethyl-methacrylate-N-methacryloyl-L-tyrosine) (PHEMA-MATyr) copolymer was synthesized in the presence of both CNF and DAS by photopolymerization. After optimization of the parameters, the modified MIP-based electrochemical sensor demonstrated the ability to determine the DAS in the linear working range of 1.0 × 10−14–1.0 × 10–13 M for the standard solution and commercial serum samples with a LOD of 1.76 × 10−15 and 2.46 × 10−15, respectively. Good linearity for DAS was observed with correlation coefficients (r) of 0.996 and 0.997 for the standard solution and commercial serum samples, respectively. The recoveries of the DAS ranged from 99.45 % to 99.53 % for the tablet dosage form and commercial serum samples, with average relative standard deviations below 1.96 % in both cases. The proposed modified sensor demonstrated significant sensitivity and selectivity for the rapid determination of DAS in commercial serum samples and tablet form.