Synthesis, Structural Characterization and Electrochemical Evaluation of Schiff Base Transition Metal Complexes with Ceftazidime

Tarinc D., MUSLU H., ÇEŞME M., Gölcü A., TÜMER M., ÖZKAN S. A.

CURRENT ANALYTICAL CHEMISTRY, vol.9, no.2, pp.319-332, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.2174/157341113805218965
  • Journal Name: CURRENT ANALYTICAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.319-332
  • Keywords: Ceftazidime, schiff base complexes, cyclic voltammetry, TRANSFER RADICAL POLYMERIZATION, PHARMACEUTICAL DOSAGE FORMS, BIOLOGICAL-ACTIVITY, RUTHENIUM INDENYLIDENE, VOLTAMMETRIC BEHAVIOR, CU(II) COMPLEXES, SQUARE-WAVE, LIGANDS, CEFOTAXIME, CHEMISTRY
  • Ankara University Affiliated: Yes

Abstract

In this study, transition metals (Cu(II), Co(II), Ni(II), Fe(III) and Ru(III)), complexes of Schiff base derived from (6R,7R,Z)-7-(2-(2-aminothiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetamido)-8-oxo-3-(pyridinium-ylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate, Ceftazidime; CFZ) and p-dimethylaminobenzaldehyde (DAB) were prepared and characterized by the analytical and spectroscopic methods. The analytical data show the composition of the metal complex to be [M(CFZ-DAB)Cl-n]Cl, where CFZ-DAB is the Schiff base ligand and n=1 for Cu(II), Co(II), Ni(II) and n=2 for Fe(III) and Ru(III) complexes. The conductance data indicate that all the complexes are strong-electrolytes. The compound (CFZ-DAB) behaves as a tridentate ligand. But, obtained complexes have mononuclear nature. The electrochemical properties of the metal complexes were investigated by cyclic voltammetry (CV) using glassy carbon electrode. The oxidation/reduction of metal complexes wasirreversible/reversible and exhibited diffusion controlled process depending on pH. The dependence of intensities of currents and potentials on pH, concentration, scan rate, nature of the buffer was investigated. The oxidation/reduction mechanism was proposed and discussed.