Combinatorial chemistry, combinatorial synthesis methods and technologies, combinatorial libraries and High Throughput screening (HTS) Kombi̇natoryal (bütünleşti̇ri̇ci̇) ki̇mya, kombi̇natoryal sentez yöntem ve teknoloji̇leri̇, kombi̇natoryal kütüphaneler ve Yüksek Hizda Akti̇vi̇te Tarama (YHAT)

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Işgör Y. G., Yilmaz S., Ölgen S.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.37, sa.1, ss.41-61, 2008 (Scopus)

• Yayın Türü: Makale / Derleme
• Cilt numarası: 37 Sayı: 1
• Basım Tarihi: 2008
• Doi Numarası: 10.1501/eczfak_0000000490
• Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
• Derginin Tarandığı İndeksler: Scopus
• Sayfa Sayıları: ss.41-61
• Anahtar Kelimeler: Combinatorial chemistry, High throughput screening, Ombinatorial libraries, Solid phase synthesis, Synthesis technologies
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Ankara Üniversitesi Adresli: Evet

Özet

Combinatorial chemistry has become an important tool for design and discovery of novel chemical molecules. This technique allows for the production of large numbers of different molecules simultaneously. Pharmaceutical industries use combinatorial chemistry to create libraries of organic molecules for drug screening and lead optimisation. This review takes a look at the determination of combinatorial chemistry, generating of combinatorial libraries, solid, liquid and solution phase synthesis, synthesis technologies and High Throughput Screening (HTS) methodology which is used in pharmaceutical and biotechnological research and mostly as a complemental to the combinatorial chemistry applications.