Propylthiouracil-induced hypersensitivity syndrome

AYCAN Z., Arhan E., Cetinkaya E., Vidinlisan S., Menekse N., Yucel H., ...Daha Fazla

TURKISH JOURNAL OF PEDIATRICS, cilt.48, sa.2, ss.162-165, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 2
  • Basım Tarihi: 2006
  • Dergi Adı: TURKISH JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.162-165
  • Anahtar Kelimeler: propylthiouracil, hypersensitivity, vasculitis, ANTINEUTROPHIL CYTOPLASMIC ANTIBODY, INDUCED CUTANEOUS VASCULITIS, CRESCENTIC GLOMERULONEPHRITIS, ANTITHYROID DRUGS, GRAVES-DISEASE, THERAPY, ANCA
  • Ankara Üniversitesi Adresli: Hayır

Özet

Propylthiouracil (PTU) is usually the first choice for the treatment of hyperthyroidism, but it has serious side effects such as hepatitis, cholestatic jaundice, splenomegaly and lupus-like syndrome, in addition to mild and common side effects like granulocytopenia, pruritus, urticaria and maculopapular or papular eruption. Antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis is another serious side effect. A 14-year-old female receiving PTU treatment for hyperthyroidism was referred to our clinic with fever, cough and dyspnea. The PTU dosage was first decreased but pericardial, dermal and joint involvement ascribed to PTU developed later and the drug was discontinued. ANCA-positive vasculitis due to PTU was considered when tests revealed an ANCA-positive state. We suggest that severe multisystemic vasculitis due to PTU should be considered during PTU usage.