Akademik Veri Yönetim Sistemi
Tezin Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Ankara Üniversitesi, Fen Bilimleri Enstitüsü, Biomedical Engineering, Türkiye
Tezin Onay Tarihi: 2026
Tezin Dili: İngilizce
Öğrenci: GENCAY YASAV
Danışman: Hilal Göktaş
Özet:
Chronic wounds remain a significant clinical challenge due to prolonged inflammation, high risk of infection, and impaired tissue regeneration, creating a critical need for advanced wound dressing materials with active and adaptive functionalities. In this study, chitosan- and 4-vinylpyridine (4VP)-based copolymer thin films were synthesized via plasma-enhanced chemical vapor deposition (PECVD) as potential wound dressings for chronic wound applications. The solvent-free and low-temperature PECVD process enabled the formation of homogeneous thin film structures. Copolymer formation and surface chemistry were comprehensively investigated using UV–Vis spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). XPS analyses confirmed the successful incorporation of characteristic bonds and functional groups associated with chitosan and poly(4-vinylpyridine) (P4VP) within the same film matrix, verifying copolymerization. XRD results revealed that the obtained films exhibited an amorphous structure, which is advantageous for wound dressing applications due to enhanced flexibility and surface compatibility. SEM images demonstrated the formation of uniform, crack-free thin films with controlled surface morphology. Furthermore, the antimicrobial activity of the synthesized copolymer films was evaluated against both Gram-negative Escherichia coli and Gram-positive bacteria Staphylococcus aureus, and inhibitory effects were observed not only for the chitosan–P4VP copolymer films but also for chitosan and P4VP thin films individually. Overall, the results indicate that chitosan–P4VP copolymer thin films produced by PECVD offer a promising biomaterial platform for chronic wound dressing applications by combining chemical stability, surface functionality, and antimicrobial performance.