Akademik Veri Yönetim Sistemi
Tezin Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Ankara Üniversitesi, Fen Bilimleri Enstitüsü, Biomedical Engineering, Türkiye
Tezin Onay Tarihi: 2026
Tezin Dili: İngilizce
Öğrenci: CAN AKMAN
Danışman: Hilal Göktaş
Özet:
Photodynamic Therapy (PDT) is a non-invasive method that provides better cosmetic outcomes than conventional treatments in skin cancers and can also be used in elderly patients; however, its effectiveness is limited due to the restricted tissue penetration of light, the absorption of melanin at wavelengths like those of the photosensitizer, and aggregation-induced changes in the optical properties of photosensitizers. In this thesis study, porphyrin-based copolymer thin films were synthesized using the Plasma-Enhanced Chemical Vapor Deposition (PECVD) method to overcome these limitations. Tetraphenylporphyrin (TPP) was copolymerized with the electron-donating monomers thiophene and pyrrole, and TPP-co-Thiophene/TPP-co-Pyrrole thin films were obtained in their pure forms without the use of any solvents.
As a result of the Ultraviolet-Visible spectroscopy analysis, it was determined that the TPP-Thiophene copolymer thin films exhibit absorption at a wavelength of 655nm with an approximately 10nm bathochromic shift in the Soret and Q bands. This critical finding indicates an increase in the conjugation length and demonstrates that light absorption in the visible region is enhanced in accordance with the objective of deep tissue penetration and will be less affected by the optical masking of melanin pigment. In TPP–Pyrrole films, the high reactivity and volatility the Pyrrole monomer resulted in a matrix-dominant structure that overshadowed the optical features of TPP and Thiophene. Considering the obtained data from other characterization methods, it has been demonstrated that the PECVD method is an effective technique for producing solvent-free photosensitizer films with homogeneous morphology and tunable optical properties suitable for PDT applications.