Akademik Veri Yönetim Sistemi
Yılgör Huri P. (Yürütücü)
TÜBİTAK Uluslararası İkili İşbirliği Projesi, 2535 - İran Bilim, Araştırma ve Teknoloji Bakanlığı (MSRT) ile İkili İşbirliği Programı, 2023 - 2025
Tissue engineering has opened up new possibilities for solving many of the issues associated with traditional wound healing procedures. Even though much research has been conducted on this subject, there is always a need to develop new ideas, correct present techniques, and improve existing scaffolds from a more practical standpoint. When a biomaterial is employed as a skin patch, various requirements must be considered at the same time. Nonetheless, most existing research does not include all of the relevant components and criteria (TRL 1).
Enhanced techniques such as electrospinning and 3D printing have recently advanced tissue engineering in wound healing and wound dressing creation. Electrospinning has been utilized to generate nanofibrous composites from synthetic or natural biocompatible polymers for wound dressings. Fabrication of nanofibrous mats that imitate the extracellular matrix (ECM), high volume surface ratio, flexible and porous structure, which increase cellular behavior, and wound healing acceleration are some of its notable qualities. Various synthetic (e.g., PCL, PLA, and PVA) and natural polymers (e.g., chitosan, gelatin, and silk) can be employed alone or in the form of composites to increase mechanical properties and degradation rate in this process (TRL 2, 3).
In this study, a thin printed network will be fabricated with different pore sizes and pattern geometries. The printed network will be coated with propolis to form a wound dressing top layer. Then, nanocomposite fibers will electrospun on the printed layer to form a wound dressing sublayer (TRL 4). Next, these structures will be assessed by scanning (SEM), and Fourier-transform infrared spectroscopy (FTIR) to the determination of morphology, composition, and structure. In addition, the mechanical tests, water uptake and weight loss by degradation test, oxygen permeability, followed by the drug release rate by in vitro drug release test, analyzing the drug-related wavelength, and the antibacterial effects will be investigated. Regarding the human dermal fibroblasts culture, cytotoxicity, cell adhesion, and proliferation will be determined. In the end, the optimum sample would be chosen for the rest of the biological assessments. (TRL 5)