Akademik Veri Yönetim Sistemi
Saka M. C. (Yürütücü)
7. Çerçeve Programı Projesi, 7. Çerçeve Programı Projesi, 2010 - 2015
The aim of EU-GEI is to identify the interactive genetic, clinical and
environmental determinants involved in the development, severity and
outcome of schizophrenia (EU-GEI, Schiz. Res. 2008; 102: 21-6). In order
to identify these interactive determinants, EU-GEI will employ
family-based, multidisciplinary research paradigms, which allow for the
efficient assessment of gene-environment interactions. In order to go
beyond old findings from historical convenience cohorts with crude
measures of environmental factors and clinical outcomes, the focus in
EU-GEI will be on recruitment of new, family-based clinical samples with
state-of-the-art assessments of environmental, clinical and genetic
determinants as well as their underlying neural and behavioural
mechanisms. New statistical tools will be developed to combine the
latest multilevel epidemiological with the latest genome-wide genetic
approaches to analysis. Translation of results to clinical practice will
be facilitated by additional experimental research and risk assessment
bioinformatics approaches. This will result in the identification of
modifiable biological and cognitive mechanisms underlying
gene-environment interactions and the construction of Risk Assessment
Charts and Momentary Assessment Technology tools which can be used for
(i) early prediction of transition to psychotic disorder in help-seeking
individuals with an at-risk mental state and (ii) early prediction of
course and outcome after illness onset. In order to reach these goals,
EU-GEI has assembled a multidisciplinary team of top schizophrenia
researchers who have the range of skills required to deliver a program
of research that meets all the call’s requirements and who have access
to / will collect a number of unique European samples. The partners in
EU-GEI represent the nationally funded schizophrenia / mental health
networks of the UK, Netherlands, France, Spain, Turkey and Germany as
well as other partners.