Relapsing-Remitting Multiple Skleroz Hastalarında Bilişsel Bozulma Sıklığı


Sorgun M. H.

Diğer Özel Kurumlarca Desteklenen Proje, 2014 - 2017

  • Proje Türü: Diğer Özel Kurumlarca Desteklenen Proje
  • Başlama Tarihi: Ekim 2014
  • Bitiş Tarihi: Mayıs 2017

Proje Özeti

Background: Cognitive impairment (CI) is a common problem in multiple sclerosis (MS), may occur either in

early or late phase of the disease, and impairs quality of life.

Objectives: This study aimed to determine the prevalence of CI and related risk factors in relapsing-remitting MS

(RRMS) patients in Turkey.

Methods: The present cross-sectional, multi-center, and nationally representative study included RRMS patients.

Sociodemographic characteristics, cognitive functions and additional outcomes were compared between patients

with and without CI.

Results: The analyses included 487 RRMS patients. According to the BRB-N battery results, CI prevalence was

53.7%. There was a negative significant correlation of BRB-N subtests with age, disease duration, and EDSS and

MSNQ-patient rated scores. On the logistic regression analysis, increased age, living in village/rural area, high

income level, and high EDSS score were significant increasing risk factors in the development of CI.

Conclusions: This is the first national cognitive data obtained from MS in Turkey, which is a country between

Europe and Asia and thus has characteristics of both continents. The similarity of the results of the present study

obtained from Turkey to the Western-based data indicates that CI is universal in MS and the main factors

affecting CI have not changed.