For topical treatment of soft tissue injuries like ankle sprain, a desirable approach should be to quickly relieve subjects’ pain while, at the same time, favoring reduction of swelling and recovery of the normal capillary network function. It should also be safe, well tolerated, easy to use, and accessible. Often all these requirements cannot be satisfactorily met by a single active principle. Therefore, combinations of substances with different modes of action are considered. Reparil Gel N formulation combines Diethylamine salicylate (DEAS), a NSAID with high rate of skin absorption, and Escin, the active component of Aesculus hippocastanum, the horse chestnut seed, which itself has been used as a traditional medicine for centuries, and is still used to treat certain conditions, including hemorrhoids, varicose veins, hematoma, and venous congestion.